Inflammatory Responses in Brain Ischemia
نویسندگان
چکیده
منابع مشابه
Effect of renal ischemia-reperfusion on lung injury and inflammatory responses in male rat
Objective(s):Acute kidney injury (AKI), a syndrome characterized by decreased glomerular filtration, occurs in every 1 of 5 hospitalized patients. Renal ischemia-reperfusion, one of the main causes of AKI, is of particular importance in the setting of kidney transplantation. Materials and Methods: Sixty male rats were divided into four groups including control, nephrectomy, sham surgery and re...
متن کاملBrain tissue responses to ischemia.
The brain is particularly vulnerable to ischemia. Complete interruption of blood flow to the brain for only 5 minutes triggers the death of vulnerable neu-rons in several brain regions, whereas 20–40 minutes of ischemia is required to kill cardiac myocytes or kidney cells. In part, the prominent vulnerability of brain tissue to ischemic damage reflects its high metabolic rate. Although the huma...
متن کاملInflammatory responses to ischemia and reperfusion in the cerebral microcirculation.
Ischemia and reperfusion (I/R) has been shown to elicit an inflammatory response that is characterized by an increased production of reactive oxygen species, and the rolling, firm adhesion, and transendothelial migration of leukocytes in postcapillary venules. A rate-determining role for leukocyte-endothelial cell (L/E) adhesion in the initiation and propagation of reperfusion injury is support...
متن کاملMethanolic leaf extract of Punica granatum attenuates ischemia-reperfusion brain injury in Wistar rats: Potential antioxidant and anti-inflammatory mechanisms
Objective(s): This study was conducted to evaluate the cerebroprotective effect of methanolic leaf extract of Punica granatum (MePG) in Wistar rats.Materials and Methods: The MePG was initially assessed for in vitro antioxidant activity, and later evaluated on LPS-induced RAW 264.7 cell line assay. Finally, the MePG was evaluated against ischemia-reperfusion (I/R) induced brain injury in Wistar...
متن کاملCarthamus tinctorius L. ameliorates brain injury followed by cerebral ischemia-reperfusion in rats by antioxidative and anti-inflammatory mechanisms
Objective(s): Carthamus tinctorius L. (CT) or saffloweris widely used in traditional Chinese medicine. This study investigated the effects of CT extract (CTE) on ischemia–reperfusion (I/R) brain injury and elucidated the underlying mechanism. Materials and Methods: The I/R model was conducted by occlusion of both common carotid arteries and right middle cerebral artery for 90 min followed by 24...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Current Medicinal Chemistry
سال: 2015
ISSN: 0929-8673
DOI: 10.2174/0929867322666150209154036